Ozempic, Mounjaro, Wegovy – Comparison for Weight Loss
Losing weight can be a big challenge. At times, after doing everything right, you hit a weight loss plateau. That is why prescription weight loss injectable medications such as Ozempic, Mounjaro and Wegovy have been a godsend. They make it super easy to lose weight.
In this blog, we compare these three popular weight loss drugs on the market and outline their pros and cons so that you can decide which one suits you the best. Let’s dive in!
Difference between Ozempic, Mounjaro & Wegovy
| Medication | Generic Name | Drug class | Approved usage(s) | Prescribed usage(s) |
| Mounjaro | Tirzepatide | GLP-1 & GIP receptor agonist | Type 2 diabetes | Type 2 diabetes/overweight/obesity |
| Ozempic | Semaglutide | GLP-1 receptor agonist | Type 2 diabetes/cardiovascular disease prevention | Type 2 diabetes/cardiovascular disease prevention/overweight/obesity |
| Wegovy | Semaglutide | GLP-1 receptor agonist | Overweight/obesity/cardiovascular disease prevention | Overweight/obesity/cardiovascular disease prevention |
Ozempic and Wegovy are GLP-1 (glucagon-like peptide 1) receptor agonists. They have semaglutide as their main ingredient. The GLP-1 receptor agonists mimic hormones that regulate hunger. They slow down gastric emptying and provide a feeling of fullness for longer.
Mounjaro is a dual agonist. It mimics the GIP (Glucose-Dependent Insulinotropic Polypeptide) hormone as well as GLP-1 for weight loss. Its main ingredient is tirzepatide.
These prescription weight loss drugs are approved to induce weight loss in adults with
- BMI =<30 (obesity)
- BMI =<27 (overweight) with weight-related health conditions like high blood pressure, type 2 diabetes or high cholesterol
Ozempic vs Wegovy
For an apt comparison of Ozempic vs Wegovy for weight loss, let’s outline how do Ozempic and Wegovy work. Ozempic and Wegovy both contain the same main ingredient – semaglutide. They make it easier for people to lose weight. They also help manage diabetes by affecting appetite and increasing satiety.
Both Ozempic and Wegovy have similar mechanisms. But they have different dosage schedules. This affects their effectiveness in inducing weight loss. The efficacy of Wegovy for weight loss has been proven in clinical trials. But Ozempic is only tested for Type 2 diabetes management yet, outlining weight loss as a side effect.
With a low calorie diet and exercise, people lost on average 15% of their body weight on semaglutide (Wegovy). In Wegovy vs Ozempic, the difference between the two weight loss drugs is that Ozempic contains a lower dose of semaglutide than Wegovy. Both are prescribed for weight loss by health care professionals – Ozempic for weight loss off-label and Wegovy for weight loss specifically.
Ozempic & Wegovy (semaglutide) vs Mounjaro (tirzepatide)
Mounjaro (tirzepatide) is a dual agonist. It works by activating GLP-1 and GIP receptors. By stimulating two hormone pathways, Mounjaro increases insulin secretion and leads to greater blood sugar control. It more effectively suppresses appetite and promotes satiety, leading to weight loss as a side effect.
That is why it is often prescribed off-label for weight loss. People on Mounjaro lose up to 20-22% of their body weight, while weight loss with Ozempic and Wegovy is 15%.
Ozempic vs Wegovy vs Mounjaro: Common Side Effects
| Weight Loss Medication | Common Side Effects |
| Ozempic | Nausea, diarrhea |
| Wegovy | Nausea, constipation, vomiting, headache, stomachache, fatigue, diarrhea, |
| Mounjaro | Nausea, vomiting diarrhea, constipation |
When you start taking any prescription weight loss medication, you are bound to suffer from common side effects as your body adjusts to the drug. That is why the starting dose of any weight loss prescription drug is the lowest in the beginning. The severity of these depends on individual biochemistry as well. Talk to your healthcare provider to decide which medication is suited for you. They will asses your medical history and prescribe you the suitable medication.
Conclusion
If a medication isn’t suiting you due to the side effects or is not inducing weight, you can switch to another under the guidance of your doctor. Always consult your healthcare provider in case of severe side effects or when considering a switch in medications. They will guide you right.
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